It was recently discovered that Mexicans and other Latin Americans (i.e. Mestizos & Amerindians) are at a high genetic risk for type 2 diabetes. From paper “Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico“:
Here we analysed 9.2 million single nucleotide polymorphisms (SNPs) in each of 8,214 Mexicans and other Latin Americans: 3,848 with type 2 diabetes and 4,366 non-diabetic controls. In addition to replicating previous findings2, 3, 4, we identified a novel locus associated with type 2 diabetes at genome-wide significance spanning the solute carriers SLC16A11 and SLC16A13 (P = 3.9 × 10−13; odds ratio (OR) = 1.29). The association was stronger in younger, leaner people with type 2 diabetes, and replicated in independent samples (P = 1.1 × 10−4; OR = 1.20). The risk haplotype carries four amino acid substitutions, all in SLC16A11; it is present at ~50% frequency in Native American samples and ~10% in east Asian, but is rare in European and African samples. Analysis of an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals
The racial breakdown of Mexicans is as follows:
According to the CIA World Fact Book, Mexico is:
Less than 10% European (mostly Spaniard)
And what is the ancestry of mestizos? Examining genetic ancestral markers, Rubén Lisker found the average admixture of a lower-income mestizos in Mexico City to be:
34% European [mostly Spaniard]
and 6% black
As noted by above abstract, it is believed that this genetic disposition was inherited from Neanderthals. All non-Africans have Neanderthal genes, and different non-African racial groups do not have the same Neanderthal genes. This gene for type 2 diabetes seems to be predominant among the Amerindians of the New World (hence the high risk for Mexico, which is 90% Amerindian/Mestizo). Perhaps Europeans and North Asians had this gene at one point but then lost it through 10,000 years of agriculture?
What can Mexicans (mestizos/Amerindians) do to combat this disposition? Well, for starters, find a new cuisine, as Mexicans are now the fattest people on the planet. As many health experts have recently noted, Mexican food might well be unhealthiest food around today.